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The overall goal of our laboratory is to understand the molecular basis of protein function using a
multidisciplinary approach that focuses on high resolution X-ray crystallography but includes complementary
computational modeling, molecular biology, and biochemical methods. We are studying several different systems
with a focus on understanding molecular mechanisms of activation, biochemical function, or disease processes and responses.
The systems in which we’re interested include the innate immune response, neurodegenerative disorders,
biotin-dependent metabolic enzymes, and blood coagulation.
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